Intravenous trifluoperazine (stelazine®) as a postoperative anti-emetic

Effect of Intravenous Ketamine on Prevention of Postoperative Shivering: A Comparison with Intravenous Pethedine

Introduction: Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. This study aimed to compare the impact of Ketamine and Pethidine on postoperative shivering.  Methods: In a randomized clinical trial, one hundred and thirty-five patients undergoing elective abdominal surgery were recruited for the study. The patients were...

Title: Repurposing the anti-psychotic trifluoperazine as an anti-metastasis agent

Improving the quality of anti-emetic therapy.

The outcome of anti-emetic therapy (AT) to women with gynaecological cancer receiving chemotherapy, in total 552 courses, was registered for a 1-year period. A quality improvement (QI) programme was established, based on three standardized AT regimens. Evaluation and documentation of AT effects were performed by the patients themselves, reporting the number of emetic episodes and degree of naus...

Palonosetron as an anti-emetic and anti-nausea agent in oncology

Palonosetron (Aloxi(®), Onicit(®), Paloxi(®)) is a second-generation 5-HT(3) receptor antagonist (RA) with an extended half-life of ~40 hours and high binding affinity for the 5-HT₃ receptor that is markedly different from other 5-HT(3) RAs. Phase III trials demonstrate that a single dose of palonosetron compared with traditional 5-HT₃ RAs is more effective in preventing chemotherapy-induced na...

Suppository diclofenac instead of intravenous meperidine for postoperative management

Suppository diclofenac instead of intravenous meperidine for postoperative management